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KMID : 0043320170400091087
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Archives of Pharmacal Research
2017 Volume.40 No. 9 p.1087 ~ p.1093
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Effect of processing method on platycodin D content in Platycodon grandiflorum roots
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Kwon Jae-Young
Lee Hyae-Min
Kim Na-Hyun
Lee Je-Hyun
Woo Mi-Hee
Kim Jin-Woong
Kim Yeong-Shik
Lee Dong-Ho
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Abstract
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Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC?ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC?ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.
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KEYWORD
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Platycodon grandiflorum, Platycodi Radix, Platycodin D, HPLC?ELSD, Processing method
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